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[Ref] Gastrointestinal adverse effects have consisted of gastrointestinal pain (13 %), nausea (12 %), dyspepsia (12 %), diarrhea, constipation, windiness, stomatitis, rectal blood loss, and also melena.
[Ref] Cardiovascular negative effects have actually included edema, pulsations, vasodilation, hypotension, syncope, as well as pallor.